Morphine and other opioids should not be used in children who have amplified musculoskeletal pain syndromes. It has led to deaths. A Cochrane systematic review concluded that in adults with neuropathic pain there was only equivocal evidence of efficacy. There is a risk for opioid and other drug addiction in those who use these medications.
- McNicol ED, Midbari A, Eisenberg E. Opioids for neuropathic pain. The Cochrane database of systematic reviews 2013;8:Cd006146